UCLA curators, who maintain a large collection of Manutius's printing, have described this as a 'wholesale change . Griffo's roman typeface, with several replacements of the capitals, continued to be used by Manutius's company until the 1550s, when a refresh of its equipment brought in French typefaces which had been created by Garamond, Pierre Haultin and Robert Granjon under its influence. This version was used to print Manutius' famous illustrated volume Hypnerotomachia Poliphili. In 1499, Griffo recut the capitals, changing the appearance of the typeface slightly. De Aetna was printed using a mixture of alternate characters, perhaps as an experiment, which included a lower-case p in the same style as the capital letter with a flat top. Historian Beatrice Warde suggested in the 1920s that its influence may have been due to the high quality of printing shown in the original De Aetna volume, perhaps created as a small pilot project. In France, his work inspired many French printers and punchcutters such as Robert Estienne and Claude Garamond from 1530 onwards, even though the typeface of De Aetna with its original capitals was apparently used in only about twelve books between 14. The type is sometimes known as the 'Aldine roman' after Manutius' name. Modern font designer Robert Slimbach has described Griffo's work as a breakthrough leading to an 'ideal balance of beauty and functionality', as earlier has Harry Carter. One of the main characteristics that distinguished Griffo's work from most of the earlier 'Venetian' tradition of roman type by Nicolas Jenson and others is the now-normal horizontal cross-stroke of the 'e', a letterform which Manutius popularised.

Griffo was one of the first punchcutters to fully express the character of the humanist hand that contemporaries preferred for manuscripts of classics and literary texts, in distinction to the book hand humanists dismissed as a gothic hand or the everyday chancery hand. This book, usually now called De Aetna, was a short 60-page text about a journey to Mount Etna, written by the young Italian humanist poet Pietro Bembo, who would later become a Cardinal, secretary to Pope Leo X and lover of Lucrezia Borgia. His first printing in the Latin alphabet, in February 1496 (1495 by the Venetian calendar), was a book entitled Petri Bembi de Aetna Angelum Chabrielem liber. Manutius at first printed works only in Greek. These were used as a master to stamp matrices, the moulds used to cast metal type. Griffo, sometimes called Francesco da Bologna (of Bologna), was an engraver who created designs by cutting punches in steel. The regular (roman) style of Bembo is based on Griffo's typeface for Manutius. This section is engraved as a simulation of Tagliente's handwriting other parts were set in a typeface of similar design. Giovanni Antonio Tagliente's 1524 writing manual, which inspired Bembo's italic. Bembo has been released in versions for phototypesetting and in several revivals as digital fonts by Monotype and other companies.

Prominent users of Bembo have included Penguin Books, the Everyman's Library series, Oxford University Press, Cambridge University Press, the National Gallery, Yale University Press and Edward Tufte. Since its creation, Bembo has enjoyed continuing popularity as an attractive, legible book typeface.

Monotype also created a second, much more eccentric italic for it to the design of calligrapher Alfred Fairbank, which also did not receive the same attention as the normal version of Bembo. It followed a previous more faithful revival of Manutius's work, Poliphilus, whose reputation it largely eclipsed. Monotype created Bembo during a period of renewed interest in the printing of the Italian Renaissance, under the influence of Monotype executive and printing historian Stanley Morison. The italic is based on work by Giovanni Antonio Tagliente, a calligrapher who worked as a printer in the 1520s, after the time of Manutius and Griffo. Bembo is named for Manutius's first publication with it, a small 1496 book by the poet and cleric Pietro Bembo. It is a member of the ' old-style' of serif fonts, with its regular or roman style based on a design cut around 1495 by Francesco Griffo for Venetian printer Aldus Manutius, sometimes generically called the 'Aldine roman'. Bembo is a serif typeface created by the British branch of the Monotype Corporation in 1928–1929 and most commonly used for body text.

Bembo typeface 1945